<p data-pm-slice="1 1 []">Just like all other drugs, this targeted drug can lead to certain side effects such as liver problems, profuse bleeding, bowel wall tear and heart-related conditions. Yellowing of the skin or eyes, abnormal bleeding, severe abdominal pain and chest pain should be reported to the doctor immediately. However, awareness of Regorafenib side effects in colorectal cancer patients is vital to help patients recognize potential complications and seek timely medical care.